(mek' li zeen)
Oral prescription tablets:
Antivert, Antrizine, Dramamine Less Drowsy Formula, Meni-D
Pregnancy Category B
Anti-motion sickness drug
Reduces sensitivity of the labyrinthine apparatus; probably acts at least partly by blocking cholinergic synapses in the vomiting center, which receives input from the chemoreceptor trigger zone and from peripheral nerve pathways; peripheral anticholinergic effects may contribute to efficacy.
· Prevention and treatment of nausea, vomiting, motion sickness
· Possibly effective for the management of vertigo associated with diseases affecting the vestibular system
Contraindications and cautions
· Contraindicated with allergy to meclizine or cyclizine.
· Use cautiously with lactation, narrow-angle glaucoma, stenosing peptic ulcer, symptomatic prostatic hypertrophy, bronchial asthma, bladder neck obstruction, pyloroduodenal obstruction, cardiac arrhythmias, postoperative state (hypotensive effects may be confusing and dangerous), pregnancy.
Tablets—12.5, 25, 50 mg; chewable tablets—25 mg; capsules—25, 30 mg
· Motion sickness: 25–50 mg PO 1 hr prior to travel. May repeat dose every 24 hr for the duration of the journey.
· Vertigo: 25–100 mg PO daily in divided doses.
Not recommended for use in children < 12 yr.
More likely to cause dizziness, sedation, syncope, toxic confusional states, and hypotension in elderly patients; use with caution.
Metabolism: T1/2: 6 hr
Distribution: Crosses placenta; may enter breast milk
· CNS: Drowsiness, confusion, euphoria, nervousness, restlessness, insomnia and excitement, seizures, vertigo, tinnitus, blurred vision, diplopia, auditory and visual hallucinations
· CV: Hypotension, palpitations, tachycardia
· Dermatologic: Urticaria, rash
· GI: Dry mouth, anorexia, nausea, vomiting, diarrhea or constipation
· GU: Urinary frequency, difficult urination, urinary retention
· Respiratory: Respiratory depression, death (due to overdose, especially in young children), dry nose and throat
· Increased sedation with alcohol or other CNS depressants
· History: Allergy to meclizine or cyclizine, pregnancy, narrow-angle glaucoma, stenosing peptic ulcer, symptomatic prostatic hypertrophy, bronchial asthma, bladder neck obstruction, pyloroduodenal obstruction, cardiac arrhythmias, postoperative patients, lactation, pregnancy
· Physical: Skin color, lesions, texture; orientation, reflexes, affect; ophthalmic examination; P, BP; R, adventitious sounds; bowel sounds, normal output, status of mucous membranes; prostate palpation, urinary output
· Monitor I & O, and take appropriate measures with urinary retention.
· Take as prescribed. Avoid excessive dosage. Chew the chewable tablets carefully before swallowing.
· Anti-motion sickness drugs work best if used ahead of time for prevention.
· Avoid alcohol; serious sedation could occur.
· You may experience these side effects: Dizziness, sedation, drowsiness (use caution driving or performing tasks that require alertness); epigastric distress, diarrhea, or constipation (take with food); dry mouth (practice frequent mouth care, suck sugarless lozenges); dryness of nasal mucosa (try another motion sickness, antivertigo remedy).
· Report difficulty breathing, hallucinations, tremors, loss of coordination, visual disturbances, irregular heartbeat.
Adverse effects in Italic are most common; those in Bold are life-threatening.