(gwye fen' e sin)
Allfen; AMBI 1000, 1200; Anti-Tuss; Diabetic Tussin EX; Hytuss; Hytuss 2X; Liquibid; Mucinex; Muco-Fen; Organidin NR; Robitussin, Scot-tussin Expectorant; Siltussin SA
Pregnancy Category C
Enhances the output of respiratory tract fluid by reducing adhesiveness and surface tension, facilitating the removal of viscous mucus.
· Symptomatic relief of respiratory conditions characterized by dry, nonproductive cough and in the presence of mucus in the respiratory tract.
Contraindications and cautions
· Contraindicated with allergy to guaifenesin.
· Use cautiously with pregnancy, lactation, and persistent coughs.
Syrup—100 mg/5 mL; liquid—100, 200 mg/5 mL; capsules—200 mg; SR capsules—300 mg; tablets—100, 200 mg; SR and ER tablets—600, 800, 1,000, 1,200 mg
ADULTS AND PEDIATRIC PATIENTS > 12 YR
200–400 mg PO q 4 hr. Do not exceed 2.4 g/day.
PEDIATRIC PATIENTS < 12 YR
2–6 yr: 50–100 mg PO q 4 hr. Do not exceed 600 mg/day.
6–12 yr: 100–200 mg PO q 4 hr. Do not exceed 1.2 g/day.
Metabolism: Unknown; T1/2: Unknown
Distribution and excretion: Urine
· CNS: Headache, dizziness
· Dermatologic: Rash, urticaria
· GI: Nausea, vomiting, GI discomfort
· Color interference and false results of 5-HIAA and VMA urinary determinations
Name confusion has been reported between Mucinex (guaifenesin) and Mucomyst (acetylcysteine); use caution.
· History: Allergy to guaifenesin; persistent cough due to smoking, asthma, or emphysema; very productive cough; pregnancy
· Physical: Skin lesions, color; T; orientation, affects; R, adventitious sounds
· WARNING: Monitor reaction to drug; persistent cough for more than 1 wk, fever, rash, or persistent headache may indicate a more serious condition.
· Some ER or SR formulations may be cut in half but cannot be crushed or chewed. Mucinex cannot be crushed, chewed, or cut.
· Do not take for longer than 1 wk; if fever, rash, or headache occur, consult health care provider.
· You may experience these side effects: Nausea, vomiting (eat frequent small meals); dizziness, headache (avoid driving or operating dangerous machinery).
· Report fever, rash, severe vomiting, persistent cough.
Adverse effects in Italic are most common; those in Bold are life-threatening.